Acute toxicity studies were performed in mice with proteins Cry3Bb1 and CP4 EPSPS, which showed no adverse effects even at higher doses. Another relevant fact is the fact that both proteins are rapidly digested in gastric fluids or in drastic pH conditions (they lose more than 95% of their activity in 15 seconds of incubation). Proteins also lose activity by heat treatment – ​​a condition used in cooking food. There is a history of safe consumption of RNAi molecules in plants, including those with homology to genes in humans and animals. Furthermore, there is no evidence that the consumption of nucleic acid molecules is associated with toxicity, including those associated with dsRNA-mediated gene regulation. Considering the studies on the expression level of DvSnf7 dsRNA, the highest level being 73x107 ug/g of dry mass, the potential dietary incorporation by the consumption of foods derived from MON 87411 corn would be 3300 times lower than the Toxicological Threshold value (TTC – Threshold of Toxicological Concern) for compounds that do not raise structural concerns for toxicity. Data indicate negligible levels of exposure to the product and that these are non-toxic. In addition, physiological barriers to RNA would limit the risk to human and animal health from the consumption of DvSnf7 dsRNA present in food products derived from MON87411 maize.